Gluconolactone
Also known as: Glucono Delta Lactone, GDL, INCI: Gluconolactone
A gentle polyhydroxy acid (PHA) that exfoliates and hydrates without high irritation risk.
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Get the appWhat it does
Gluconolactone is a second-generation hydroxy acid that dissolves dead skin cells on the surface, promoting cell turnover. Unlike AHAs and BHAs, its larger molecular structure means slower, shallower penetration, reducing irritation while still delivering exfoliation and hydration benefits.
Benefits
- Gentle exfoliation suitable for sensitive or compromised skin
- Humectant properties support skin hydration and barrier health
- Lower irritation risk compared to glycolic or salicylic acid
- Improves skin texture and radiance with regular use
- Well-tolerated by most skin types, including reactive skin
Who it suits
- Sensitive skin
- Reactive or compromised barrier
- Dry skin
- Those new to chemical exfoliants
- All skin types seeking gentle exfoliation
How to use
Use 2–3 times weekly in a cleanser, toner, or leave-on serum, depending on product strength and your skin tolerance. Start with lower frequency and increase gradually.
Pairs well with
Niacinamide, Hyaluronic acid, Ceramides, Soothing agents like centella asiatica
Be careful pairing with
High concentrations of other strong exfoliants (AHA/BHA) on same day
Safety & cautions
Generally well-tolerated, but patch test first if you have very sensitive skin. Concentrations and formulation pH determine efficacy and tolerance; follow product instructions and avoid combining with multiple active exfoliants on the same day.
Educational information, not medical advice. Concentration and formulation change how an ingredient behaves.